Understanding the Link Between Methylation and MTHFR Polymorphisms

Methylation is a fundamental biochemical process that occurs in every cell of the body. It plays a key role in cardiovascular health, detoxification, DNA repair, neurotransmitter production, reproductive health, energy metabolism, and other health-related areas. However, genetic variations—such as MTHFR polymorphisms—can impact how efficiently this process occurs, potentially leading to imbalances that affect homocysteine metabolism, energy levels, and the nervous system.

The MTHFR gene provides instructions for producing an enzyme that converts inactive folic acid into its active form, 5-MTHF (5-methyltetrahydrofolate), which is necessary for methylation. Individuals with MTHFR polymorphisms may have a reduced ability to process folic acid, making it essential to supplement with the right, active forms for optimal function.

Many B-complex supplements contain Vitamin B6, an important nutrient involved in methylation and other health-related processes. However, excessive intake—especially from multiple supplements and fortified food sources—can lead to B6 toxicity, which may cause neurological symptoms such as tingling, numbness, and nerve-related discomfort.

MTHFR -6 Support is carefully formulated to provide a high-dose B-vitamin complex without Vitamin B6, offering a targeted approach for individuals who may have previously had prolonged or high-dose exposure to B6.

MTHFR -6 Support delivers seven essential B vitamins in their most bioavailable forms, ensuring optimal methylation support:

• Quatrefolic® (5-MTHF) – The active form of folate, supporting methylation and homocysteine metabolism.

• Methylcobalamin (B12) – Essential for converting homocysteine into methionine, a key step in methylation.

• Riboflavin-5-Phosphate (B2) – Supports MTHFR enzyme function and enhances folate metabolism.

• Thiamine (B1), Niacin (B3), Pantothenic Acid (B5), Biotin (B7) – Additional B vitamins that contribute to energy production, nervous system function, and cellular health.

By omitting B6, MTHFR -6 Support reduces the risk of excessive accumulation while still providing comprehensive methylation support for individuals with MTHFR polymorphisms, chronic illness, or nutrient absorption challenges.

✔ Methylation-focused formulation with active folate (Quatrefolic®) and B12 (Methylcobalamin)

✔ B6-free to reduce the risk of excess accumulation and sensitivity

✔ Supports homocysteine metabolism , detoxification, and neurological health

✔ Designed for individuals with MTHFR polymorphisms needing targeted B-vitamin support

✔ Vegan and hypoallergenic , free from artificial additives, gluten, and dairy