The Science Behind S-Acetyl Glutathione

Written by: MakeWell

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Published on

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Time to read 1 min

Abstract graphic background with the words  S-Acetyl Glutathione

What is Glutathione?


Glutathione is a powerful antioxidant composed of three amino acids. It plays a crucial role in protecting cells from oxidative stress, supporting the immune system, and aiding in detoxification. However, standard reduced Glutathione (GSH) is often unstable and therefore has low bioavailability when taken orally.

Why Choose S-Acetyl Glutathione (SAG)?


Enhanced Stability and Absorption: Unlike regular GSH, S-Acetyl Glutathione is chemically altered with an added acetyl group on the sulfur atom, enhancing its stability and protecting it from oxidation. This modification allows SAG to remain intact through the digestive system and be directly absorbed by cells, providing superior bioavailability.


Direct Cellular Utilisation: Once absorbed, SAG is efficiently converted into active glutathione within cells. This ensures maximum efficacy in combating oxidative stress and supporting overall health.


Scientifically Backed Benefits: Research shows that SAG is more stable in blood plasma than regular Glutathione and can increase intracellular GSH levels, providing robust antioxidant defence and support for various health-related areas.


Key Advantages of S-Acetyl Glutathione:


Superior Stability – The acetylation process protects SAG from premature breakdown, ensuring more effective delivery.


✔ Higher Bioavailability – Unlike regular GSH, SAG can pass through the digestive system intact and be absorbed directly by cells.


Powerful Antioxidant Support – Helps neutralise free radicals, reduce oxidative stress, and support overall cellular health.


Efficient Conversion – Once inside the body, SAG is readily transformed into active glutathione, maximising its benefits.


Vegan & Non-GMO – Free from genetically modified organisms and suitable for vegetarians and vegans.

How S-Acetyl Glutathione Works

SAG is a prodrug, meaning it is designed to convert into active glutathione within the body. The acetyl group attached to its sulfur atom enhances its stability and allows it to remain intact through the digestive tract. Once inside the cells, enzymes remove the acetyl group, restoring it to fully active glutathione. This process ensures:


Better cellular uptake compared to regular glutathione supplements


Improved plasma stability for improved delivery efficacy


Increased intracellular GSH levels to enhance detoxification and immune defence

Scientifically Backed Benefits


Research suggests that SAG offers superior protection against oxidative stress and is more effective at replenishing intracellular glutathione levels compared to traditional glutathione supplements. By supporting detoxification pathways, reducing inflammation, and enhancing immune function, SAG plays a vital role in maintaining overall health.

Elevate Your Cellular Health with S-Acetyl Glutathione


If you’re looking for a scientifically advanced way to support detoxification, combat oxidative stress, and enhance immune resilience, S-Acetyl Glutathione is the superior choice. Experience the benefits of a stable, highly bioavailable form of glutathione designed for optimal cellular health.

Shop S-Acetyl Glutathione 300